Din seria despre vaccine

Pentru persoanele care s-au atarnat sceptic fata de articolul meu despre vaccine:

Compania americana Baxter a introdus pe piata europeana vaccine, care in loc sa contina virus de gripa slabit, continea virus sanatos de gripa aviara.

Desigur, presa romaneasca nu va vorbeste despre asta – ea e preocupata de alte chestii. Stirea este stearsa de pe internet (daca nu stearsa, atunci ascunsa de catre motoarele de cautare).

Cititi si aici si aici.

Ca sa nu dispara intr-o buna zi, eu voi republica pe blog, in original:


Officials investigate how bird flu viruses were sent to unsuspecting labs

Officials are trying to get to the bottom of how vaccine manufacturer Baxter International Inc. made „experimental virus material” based on a human flu strain but contaminated with the H5N1 avian flu virus and then distributed it to an Austrian company.

That company, Avir Green Hills Biotechnology, then disseminated the supposed H3N2 virus product to subcontractors in the Czech Republic, Slovenia and Germany. Authorities in the four European countries are looking into the incident, and their efforts are being closely watched by the World Health Organization and the European Centre for Disease Control.

Though it appears none of the 36 or 37 people who were exposed to the contaminated product became infected, the incident is being described as „a serious error” on the part of Baxter, which is on the brink of securing a European licence for an H5N1 vaccine. That vaccine is made at a different facility, in the Czech Republic.

„For this particular incident … the horse did not get out (of the barn),” Dr. Angus Nicoll of the ECDC said from Stockholm.

„But that doesn’t mean that we and WHO and the European Commission and the others aren’t taking it as seriously as you would any laboratory accident with dangerous pathogens – which you have here.”

Accidental release of a mixture of live H5N1 and H3N2 viruses – if that indeed happened – could have resulted in dire consequences. Nicoll said officials still aren’t 100 per cent sure the mixture contained live H5N1 viruses. But given that ferrets exposed to the mixture died, it likely did.

H5N1 doesn’t easily infect people, but H3N2 viruses do. They are one of two types of influenza A viruses that infect people each flu season.

If someone exposed to the mixture had been co-infected with H5N1 and H3N2, the person could have served as an incubator for a hybrid virus able to transmit easily to and among people. That mixing process, called reassortment, is one of two ways pandemic viruses are created.

Research published last summer by scientists at the U.S. Centers for Disease Control found that in the laboratory, H5N1 and H3N2 viruses mated readily. While less virulent than H5N1, a number of the offspring viruses appeared to retain at least a portion of the killing power of their dangerous parent.

Baxter International, which is based in Deerfield, Ill., said the contamination was the result of an error in its research facility in Orth-Donau, Austria.

The facility had been contracted by Avir Green Hills to make what Baxter refers to as „experimental virus material” based on human H3N2 viruses.

Christopher Bona, Baxter’s director of global bioscience communications, said the liquid virus product was not a vaccine and was developed for testing purposes only. He deferred questions about the purpose of the testing to Avir Green Hills, but said the batch was to be used in animals and was never intended for use in humans.

Avir Green Hills said in an email that it took possession of the material in late December. It later sent the product to the sub-contractors. The email said the material was stored and handled throughout under high biosafety conditions.

Alarm bells rang in early February when researchers at the Czech sub-contractor inoculated ferrets with the material and the animals promptly died. Baxter learned about the problem on Feb. 6, Bona said from Deerfield.

Ferrets are susceptible to human flu strains, but they don’t die from those infections. Preliminary investigation found the material was contaminated with H5N1 flu virus, which is lethal to ferrets.

Nicoll said the fact the ferrets died supports the working assumption that there were live H5N1 viruses in the material Baxter produced.

Bona said Baxter has identified how the contamination happened and has taken steps to ensure it doesn’t happen again. He said Austrian authorities audited Baxter’s Orth-Donau research operations after the problem came to light and are satisfied with the steps taken.

Baxter is the only flu vaccine manufacturer to work with wild type flu viruses, felt to be more dangerous than the altered and attenuated (weakened) viruses other manufacturers use.

The company uses what is known as BSL3 level precautions in all its vaccine research facilities, Bona said. (Researchers at the U.S. CDC use BSL3-plus biocontainment when working with H5N1 viruses, a spokesperson for the agency said.)

People familiar with biosecurity rules are dismayed by evidence that human H3N2 and avian H5N1 viruses have somehow co-mingled in the Baxter research facility. That should not be allowed to happen, a number of experts insisted.

The company isn’t shedding much light on how it did.

„It was a combination of just the process itself, (and) technical and human error in this procedure,” Bona said. When asked to elaborate, he said to do so would give away proprietary information about Baxter’s production process.

Bona said when Baxter realized its error, it helped the various companies destroy the contaminated material and clean up their facilities. And staff who had been exposed to the contaminated product were assessed and monitored by infectious diseases doctors. They were also offered the antiviral drug oseltamivir (Tamiflu).

Baxter’s error is reminiscent of a 2005 incident where a U.S. manufacturer of kits used by laboratories to test their detection capabilities included vials of H2N2 virus in several thousand proficiency kits. H2N2, the virus that caused the 1957 pandemic, has not circulated since 1968 and is thought to be a prime candidate to cause the next pandemic.

That mistake, discovered by Canada’s National Microbiology Laboratory, set authorities around the world scrambling to retrieve and destroy the vials of virus, which had been sent to labs in 18 countries.

Copyright © 2009 The Canadian Press. All rights reserved.



Baxter: Product contained live bird flu virus

The company that released contaminated flu virus material from a plant in Austria confirmed Friday that the experimental product contained live H5N1 avian flu viruses.

And an official of the World Health Organization’s European operation said the body is closely monitoring the investigation into the events that took place at Baxter International’s research facility in Orth-Donau, Austria.

“At this juncture we are confident in saying that public health and occupational risk is minimal at present,” medical officer Roberta Andraghetti said from Copenhagen, Denmark.

“But what remains unanswered are the circumstances surrounding the incident in the Baxter facility in Orth-Donau.”

The contaminated product, a mix of H3N2 seasonal flu viruses and unlabelled H5N1 viruses, was supplied to an Austrian research company. The Austrian firm, Avir Green Hills Biotechnology, then sent portions of it to sub-contractors in the Czech Republic, Slovenia and Germany.

The contamination incident, which is being investigated by the four European countries, came to light when the subcontractor in the Czech Republic inoculated ferrets with the product and they died. Ferrets shouldn’t die from exposure to human H3N2 flu viruses.

Public health authorities concerned about what has been described as a “serious error” on Baxter’s part have assumed the death of the ferrets meant the H5N1 virus in the product was live. But the company, Baxter International Inc., has been parsimonious about the amount of information it has released about the event.

On Friday, the company’s director of global bioscience communications confirmed what scientists have suspected.

“It was live,” Christopher Bona said in an email.

The contaminated product, which Baxter calls “experimental virus material,” was made at the Orth-Donau research facility. Baxter makes its flu vaccine — including a human H5N1 vaccine for which a licence is expected shortly — at a facility in the Czech Republic.

People familiar with biosecurity rules are dismayed by evidence that human H3N2 and avian H5N1 viruses somehow co-mingled in the Orth-Donau facility. That is a dangerous practice that should not be allowed to happen, a number of experts insisted.

Accidental release of a mixture of live H5N1 and H3N2 viruses could have resulted in dire consequences.

While H5N1 doesn’t easily infect people, H3N2 viruses do. If someone exposed to a mixture of the two had been simultaneously infected with both strains, he or she could have served as an incubator for a hybrid virus able to transmit easily to and among people.

That mixing process, called reassortment, is one of two ways pandemic viruses are created.

There is no suggestion that happened because of this accident, however.

“We have no evidence of any reassortment, that any reassortment may have occurred,” said Andraghetti.

“And we have no evidence of any increased transmissibility of the viruses that were involved in the experiment with the ferrets in the Czech Republic.”

Baxter hasn’t shed much light — at least not publicly — on how the accident happened. Earlier this week Bona called the mistake the result of a combination of “just the process itself, (and) technical and human error in this procedure.”

He said he couldn’t reveal more information because it would give away proprietary information about Baxter’s production process.

Andraghetti said Friday the four investigating governments are co-operating closely with the WHO and the European Centre for Disease Control in Stockholm, Sweden.

“We are in very close contact with Austrian authorities to understand what the circumstances of the incident in their laboratory were,” she said.

“And the reason for us wishing to know what has happened is to prevent similar events in the future and to share lessons that can be learned from this event with others to prevent similar events. … This is very important.”


H5N1 Labor-Kontamination in Europa: LifeGen.de verdoppelt Leserzahlen

Osterode am Harz (ots) – Die analytische und kritische Berichterstattung von LifeGen.de kommt bei den globalen Nutzern an: Über 22.000 Unique User besuchten allein im Februar die Site (Stand 27.2.2009), ein Monat zuvor waren es noch rund 10.000 gewesen. Auch das Alexa-Ranking zeigt weiter nach oben: Global stehen wir nun auf Platz 217.926, in den USAavancierten wir auf Rang 837.055 nach 1,4 Mio. noch vor zwei Wochen. „Der Ansturm stellt uns vor neue Herausforderungen”, kommentiert CEO Vlad Georgescu den Trend, und: „Wir suchen intensiv nach Investoren und Teilhabern, denen eine solide, unabhängige und analytische Berichterstattung wichtiger ist als die schnelle Rendite”. Die in Fachkreisen als Viren-Tschernobyl bezeichnete Labor-Kontamination mit pathogenen Vogelgrippe-Viren der Stämme H5N1 und H3N2 durch den Pharmakonzern Baxter in gleich vier Ländern der EU zeige die Notwendigkeit eines Watch-Dienstes wie LifeGen.de: „Die großen Medien hierzulande haben den Fall praktisch verschlafen – Deutschland ist aber davon betroffen”, erklärt Georgescu. Die Berichterstattung von LifeGen.de habe indes auch der Newsservice GOOGLE FINANCE in den USA aufgegriffen – was schon am gestrigen Donnerstag anhand des Baxter-Aktiencharts deutlich zu erkennen war.Tatsächlich setzt LifeGen.de im Vergleich zu vielen anderen Medien seit Jahren auf ein eigenes Konzept: Unliebsame Entwicklungen werden rechtzeitig und direkt aufgezeigt, gleichzeitig Alternativen führender Wissenschaftsinstitute und Organisationen beleuchtet. „Da eine Abhängigkeit zu Werbeetats nicht besteht und auch sonst keine verdeckten Finanzierer die Site stützen, können wir uns einen harten, investigativen Journalismus leisten”, erklärt Marita Vollborn, Chefredakteurin des Magazins.

Als Wunschpartner oder Einstiegskandidaten bei LifeGen.de wünsche man sich technologisch starke und fiananziell unabhängige Unternehmen wie Google, Microsoft, oder die Bill and Melinda Gates Stiftung, heißt es weiter aus Osterode am Harz. „Google in Mountain View und LifeGen.de in den Harz Mountains ließe sich wunderbar vermarkten”, scherzt Georgescu, und fügt hinzu: „Aber im Grunde sehen wir genau in solchen Konstellationen eine Chance auf journalistische Sites der Zukunft die, so wie wir, Katastrophen á la Finanzkrise und Jobabbau schon vor Jahren vorhersagten”. Zwar habe man intern überlegt, das Portal für fünf Millionen USD zu verkaufen, um mit dem Geld neue Projekte anzugehen, heißt es dazu aus Osterode. Doch die enorme globale Nachfrage und Akzeptanz ließen diesen Schritt derzeit als nicht mehr sinnvoll erscheinen. „Wir wollen uns vergrößern, und es gibt viel zu tun”, sagt Vollborn.

Zu den aktuellen Nutzern von Lifegen.de gehören Bundesbehörden, Regierungen, US-amerikanische Sicherheitsinstitutionen und zahlreiche Konzerne, Unternehmen und Universitäten weltweit. Politik und Medien zählen ebenfalls zu den regelmäßigen Lesern des special interest Dienstes.

Mehr Infos unter www.lifegen.de


Vlad Georgescu

Schwimmbadstr. 29
37520 Osterode am Harz

email: vg@lifegen.de
Internet: www.lifegen.de
fon: +49-5522-3159133

Registergericht: Amtsgericht Göttingen, HRB 200658


  1. Posted 10 martie, 2009 at 6:07 pm | Permalink | Răspunde

    nu inteleg cum le gasesti …esti tare informat !

  2. Badan Sergiu
    Posted 11 martie, 2009 at 2:50 pm | Permalink | Răspunde

    Le gasesc pe resurse rusesti, chinezesti, iraniene, adica din tarile „nedemocratice” si fara „presa libera”.

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  1. By Gripa porcina « Badan Blog on 1 mai, 2009 at 6:15 pm

    […] Aici este un articol despre un caz asemanator. […]

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